CYTOTOXIC AND GENOTOXIC EFFECTS OF CALCIUM SILICATES ON HUMAN-LYMPHOCYTES INVITRO

被引：3
作者：
ASLAM, M
RAHMAN, Q
机构：
[1] Industrial Toxicology Research Centre, Lucknow
来源：
MUTATION RESEARCH | 1993年 / 300卷 / 01期
关键词：
CALCIUM SILICATE; HUMAN LYMPHOCYTES; SISTER-CHROMATID EXCHANGES; CHROMOSOMAL ABERRATIONS; PROLIFERATION RATE INDEX;
D O I：
10.1016/0165-1218(93)90138-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Calcium silicate has been considered as a possible replacement for asbestos due to its heat and fire resistance. We describe the cytotoxic and genotoxic potential of calcium silicate using peripheral human blood lymphocytes. Calcium silicates at concentrations of 10 and 100 mug/ml significantly increased the frequencies of chromosomal aberrations (CAs) and sister-chromatid exchanges (SCEs). The increases in CAs and SCEs were dose-dependent, though not linearly. A significant decrease in the proliferation rate index was observed with increased dose of calcium silicates. The induction of chromatid-type aberrations indicates that the clastogenic activity of calcium silicate is S-phase-dependent.
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页码：45 / 48
页数：4
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