COCAINE-INDUCED DISTURBANCES OF CORTICOGENESIS IN THE DEVELOPING MURINE BRAIN

被引：110

作者：

GRESSENS, P

KOSOFSKY, BE

EVRARD, P

机构：

[1] CATHOLIC UNIV LOUVAIN,SCH MED,NEUROL DEV LAB,AV HIPPOCRATE 10-1303,B-1200 BRUSSELS,BELGIUM

[2] MASSACHUSETTS GEN HOSP,DEPT PEDIAT NEUROL,BOSTON,MA 02114

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 01期

关键词：

COCAINE; GLIOGENESIS; MOUSE; NEOPALLIUM; NEUROGENESIS;

D O I：

10.1016/0304-3940(92)90694-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Exposure of fetuses to cocaine can induce behavioral disturbances and structural modifications of the CNS. Cocaine was injected into pregnant mice from the eighth day of gestation until term and the brains of their offspring were examined at the light and EM levels. Cocaine severely disturbs neocortical architecture, disrupting horizontal and vertical lamination, and inducing abnormal array of the axonal-dendritic bundles. Cocaine also alters several steps of gliogenesis. The severity of the malformations is variable, but evident in all exposed animals.

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页码：113 / 116

页数：4

相关论文

共 15 条

[1] COCAINE ACUTELY INHIBITS DNA-SYNTHESIS IN DEVELOPING RAT-BRAIN REGIONS - EVIDENCE FOR DIRECT ACTIONS [J].

ANDERSONBROWN, T ;

SLOTKIN, TA ;

SEIDLER, FJ .

BRAIN RESEARCH, 1990, 537 (1-2) :197-202

[2] NEOCORTICAL HISTOGENESIS IN NORMAL AND REELER MICE - A DEVELOPMENTAL-STUDY BASED UPON [H-3] THYMIDINE AUTORADIOGRAPHY [J].

CAVINESS, VS .

DEVELOPMENTAL BRAIN RESEARCH, 1982, 4 (03) :293-302

[3] MONO-AMINERGIC AFFERENTS TO THE NEOCORTEX - A DEVELOPMENTAL HISTOFLUORESCENCE STUDY IN NORMAL AND REELER MOUSE EMBRYOS [J].

CAVINESS, VS ;

KORDE, MG .

BRAIN RESEARCH, 1981, 209 (01) :1-9

[4] PRENATAL COCAINE EXPOSURE IN THE LONG-EVANS RAT .1. DOSE-DEPENDENT EFFECTS ON GESTATION, MORTALITY, AND POSTNATAL MATURATION [J].

CHURCH, MW ;

OVERBECK, GW ;

ANDRZEJCZAK, AL .

NEUROTOXICOLOGY AND TERATOLOGY, 1990, 12 (04) :327-334

[5] STRUCTURAL AND FUNCTIONAL-EFFECTS OF PRENATAL COCAINE EXPOSURE IN ADULT-RAT BRAIN [J].

DOWEDWARDS, DL ;

FREED, LA ;

FICO, TA .

DEVELOPMENTAL BRAIN RESEARCH, 1990, 57 (02) :263-268

[6] EFFECTS OF COCAINE ON RAT EMBRYO DEVELOPMENT INVIVO AND IN CULTURES [J].

ELBIZRI, H ;

GUEST, I ;

VARMA, DR .

PEDIATRIC RESEARCH, 1991, 29 (02) :187-190

[7] GLIAL-NEURONAL RELATIONSHIP IN THE DEVELOPING CENTRAL NERVOUS-SYSTEM - A HISTOCHEMICAL ELECTRON MICROSCOPE STUDY OF RADIAL GLIAL-CELL PARTICULATE GLYCOGEN IN NORMAL AND REELER MICE AND THE HUMAN-FETUS [J].

GADISSEUX, JF ;

EVRARD, P .

DEVELOPMENTAL NEUROSCIENCE, 1985, 7 (01) :12-32

[8] EARLY NEUROGENESIS AND TERATOGENESIS IN WHOLE MOUSE EMBRYO CULTURES - HISTOCHEMICAL, IMMUNOCYTOLOGICAL AND ULTRASTRUCTURAL-STUDY OF THE PREMIGRATORY NEURONAL-GLIAL UNITS IN NORMAL MOUSE EMBRYO AND IN MOUSE EMBRYOS INFLUENCED BY COCAINE AND RETINOIC ACID [J].

GRESSENS, P ;

GOFFLOT, F ;

VANMAELEFABRY, G ;

MISSON, JP ;

GADISSEUX, JF ;

EVRARD, P ;

PICARD, JJ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1992, 51 (02) :206-219

[9]

GRESSENS P, 1992, BIOL NEONATE, V61, P4

[10]

Kosofsky B E, 1991, NIDA Res Monogr, V114, P128