POSSIBLE INVOLVEMENT OF CA2+-RELATED INWARD CURRENT IN P2-PURINOCEPTOR-MEDIATED DEPOLARIZATION OF THE GUINEA-PIG VAS-DEFERENS

被引：1
|
作者：
INOMATA, H
JI, JJ
UTAGAWA, A
机构：
[1] TOHOKU UNIV,SCH MED,DEPT APPL PHYSIOL,SENDAI,MIYAGI 980,JAPAN
[2] TOHOKU UNIV,FAC AGR,FOOD HYG LAB,SENDAI 981,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 217卷 / 01期
关键词：
VAS DEFERENS (GUINEA-PIG); CA2+-RELATED INWARD CURRENTS; AMP-PNP(5'-ADENYLYLIMIDOPHOSPHATE); P2; PURINOCEPTORS;
D O I：
10.1016/0014-2999(92)90516-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of a Ca2+ antagonist or Ca2+ chelator on the membrane responses elicited by P2-purinoceptor activation was examined in current- and voltage-clamped muscle from the guinea-pig vas deferens. The non-hydrolyzable ATP-analogue 5'-adenylylimidophosphate (AMP-PNP) depolarized the membrane and the associated inward current. Superfusion with Ca2+-free solution containing Co2+ or EGTA markedly suppressed the AMP-PNP-induced membrane response, thereby suggesting that the inward current responsible for the depolarizing effect of AMP-PNP may involve activation of a Ca2+-related conductance.
引用
收藏
页码：93 / 96
页数：4
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