5-FLUOROURACIL, EPIRUBICIN AND CYCLOPHOSPHAMIDE (FEC COMBINATION) IN ADVANCED BREAST-CANCER

被引：1

作者：

ZAMAGNI, C ^{[1
]}

MARTONI, A ^{[1
]}

ERCOLINO, L ^{[1
]}

BARONI, M ^{[1
]}

TANNEBERGER, S ^{[1
]}

PANNUTI, F ^{[1
]}

机构：

[1] OSPED S ORSOLA MALPIGHI,DIV ONCOL,VIA ALBERTONI 15,I-40138 BOLOGNA,ITALY

来源：

JOURNAL OF CHEMOTHERAPY | 1991年 / 3卷 / 02期

关键词：

ADVANCED BREAST CANCER; 5-FLUOROURACIL; EPIRUBICIN; CYCLOPHOSPHAMIDE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty patients with advanced breast cancer, not pretreated with chemotherapy for advanced disease, received a poly-chemotherapy regimen containing 5-fluorouracil (500 mg/m2 iv), epirubicin (50 mg/m2 iv) and cyclophosphamide (500 mg/m2 iv) every four weeks. All patients were evaluable for response and for toxicity. No complete remissions were observed, while 13 patients (43.5%) achieved a partial remission for a median duration of 46 weeks. The main side-effects were alopecia (grade 2-3 in 57%), leukopenia (grade 3-4 in 33%) and nausea/vomiting (grade 3-4 in 27%). In three cases we observed laboratory signs of cardiotoxicity without clinical symptoms.

引用

页码：126 / 129

页数：4