APPLICATION OF PHARMACOKINETIC-PHARMACODYNAMIC MODELING FOR THE COMPARISON OF QUINAZOLINE ALPHA-ADRENOCEPTOR AGONISTS IN NORMOTENSIVE VOLUNTEERS

被引：25
作者：
MEREDITH, PA
ELLIOTT, HL
KELMAN, AW
REID, JL
机构：
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1985年 / 7卷 / 03期
关键词：
D O I：
10.1097/00005344-198505000-00019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：532 / 537
页数：6
相关论文
共 14 条
[1]   PRAZOSIN, PHARMACOKINETICS AND CONCENTRATION EFFECT [J].
BATEMAN, DN ;
HOBBS, DC ;
TWOMEY, TM ;
STEVENS, EA ;
RAWLINS, MD .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :177-181
[2]   IMMEDIATE CARDIOVASCULAR-RESPONSES TO ORAL PRAZOSIN - EFFECTS OF CONCURRENT BETA-BLOCKERS [J].
ELLIOTT, HL ;
MCLEAN, K ;
SUMNER, DJ ;
MEREDITH, PA ;
REID, JL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 29 (03) :303-309
[3]   THE EFFECT OF QUINIDINE AND ITS METABOLITES ON THE ELECTROCARDIOGRAM AND SYSTOLIC-TIME INTERVALS - CONCENTRATION - EFFECT RELATIONSHIPS [J].
HOLFORD, NHG ;
COATES, PE ;
GUENTERT, TW ;
RIEGELMAN, S ;
SHEINER, LB .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (02) :187-195
[4]   THE DETERMINATION OF TRIMAZOSIN AND ITS METABOLITE CP23445 IN WHOLE-BLOOD BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING FLUORESCENCE DETECTION [J].
HUGHES, MA ;
MEREDITH, PA ;
ELLIOTT, HL .
JOURNAL OF PHARMACOLOGICAL METHODS, 1984, 12 (01) :29-34
[5]   PRAZOSIN PLASMA-CONCENTRATION AND BLOOD-PRESSURE REDUCTION [J].
LAROCHELLE, P ;
DUSOUICH, P ;
HAMET, P ;
LAROCQUE, P ;
ARMSTRONG, J .
HYPERTENSION, 1982, 4 (01) :93-101
[6]   PHARMACOKINETIC AND PHARMACODYNAMIC MODELING OF TRIMAZOSIN AND ITS MAJOR METABOLITE [J].
MEREDITH, PA ;
KELMAN, AW ;
ELLIOTT, HL ;
REID, JL .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1983, 11 (04) :323-335
[7]   DETERMINATION OF THE VASODILATOR UK33274 BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING FLUORESCENCE DETECTION [J].
RUBIN, PC ;
BRUNTON, J ;
MEREDITH, P .
JOURNAL OF CHROMATOGRAPHY, 1980, 221 (01) :193-195
[8]   PRAZOSIN DYNAMICS IN HYPERTENSION - RELATIONSHIP TO PLASMA-CONCENTRATION [J].
SEIDEMAN, P ;
GRAHNEN, A ;
HAGLUND, K ;
LINDSTROM, B ;
VONBAHR, C .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (04) :447-454
[9]  
SHEINER LB, 1979, CLIN PHARMACOL THER, V25, P358
[10]   DOXAZOSIN, AN ALPHA-1-ADRENOCEPTOR ANTAGONIST - PHARMACOKINETICS AND CONCENTRATION-EFFECT RELATIONSHIPS IN MAN [J].
VINCENT, J ;
ELLIOTT, HL ;
MEREDITH, PA ;
REID, JL .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 15 (06) :719-725
12