STAGE-SPECIFIC GAMETOCYTOCIDAL EFFECT INVITRO OF THE ANTIMALARIA DRUG QINGHAOSU ON PLASMODIUM-FALCIPARUM

被引：103

作者：

KUMAR, N

HONG, Z

机构：

[1] Department of Immunology and Infectious Diseases, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, 21205, MD

来源：

PARASITOLOGY RESEARCH | 1990年 / 76卷 / 03期

关键词：

D O I：

10.1007/BF00930817

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Qinghaosu, an anti-malaria drug, has been found to kill not only asexual blood stages but also the early stages of gametocytes of Plasmodium falciparum. The effect of qinghaosu in vitro depends on the concentration of the drug as well as on the initial parasitemia level (IC50=10-20 n M with 1% initial parasitemia). Resistance of P. falciparum to other anti-malaria drugs, e.g., chloroquine and pyrimethamine, did not affect susceptibility of its asexual and sexual stages to qinghaosu. Gametocytocidal effect of qinghaosu may play a role in the interruption of malaria transmission. © 1990 Springer-Verlag.

引用

页码：214 / 218

页数：5

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