Bioorthogonal chemistry: implications for pretargeted nuclear (PET/SPECT) imaging and therapy

被引：1

作者：

Knight, James C. ^{[1
,2
]}

Cornelissen, Bart ^{[1
,2
]}

机构：

[1] Univ Oxford, ICR UK MRC Gray Inst Radiat Oncol & Biol, Oxford OX3 7LJ, England

[2] Churchill Hosp, Radiobiol Res Inst, Oxford OX3 7LJ, England

来源：

AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2014年 / 4卷 / 02期

关键词：

Pretargeting; bioorthogonal chemistry; molecular imaging; PET; SPECT; click chemistry;

D O I：

暂无

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Due to their rapid and highly selective nature, bioorthogonal chemistry reactions are attracting a significant amount of recent interest in the radiopharmaceutical community. Over the last few years, reactions of this type have found tremendous utility in the construction of new radiopharmaceuticals and as a method of bioconjugation. Furthermore, reports are beginning to emerge in which these reactions are also being applied in vivo to facilitate a novel pretargeting strategy for the imaging and therapy of cancer. The successful implementation of such an approach could lead to dramatic improvements in image quality, therapeutic index, and reduced radiation dose to non-target organs and tissues. This review will focus on the potential of various bioorthogonal chemistry reactions to be used successfully in such an approach.

引用

页码：96 / 113

页数：18

共 180 条

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