CIRCULAR-DICHROISM STUDIES OF CALICHEAMICIN-DNA INTERACTION - EVIDENCE FOR CALICHEAMICIN-INDUCED DNA CONFORMATIONAL CHANGE

被引：30

作者：

KRISHNAMURTHY, G ^{[1
]}

DING, WD ^{[1
]}

OBRIEN, L ^{[1
]}

ELLESTAD, GA ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV MED RES,LEDERLE LABS,PEARL RIVER,NY 10965

来源：

TETRAHEDRON | 1994年 / 50卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)80622-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Evidence from circular dichroism studies suggests that the binding of calicheamicin to DNA induces an optically detectable conformational change of B-form DNA. CD titration of a dodecamer containing a TCCT binding/cleavage site with calicheamicin gamma(1)(I) the aromatized calicheamicin epsilon brings about a decrease primarily in the ellipticity of the positive 270 nm signal. Binding constants for calicheamicin gamma(1)(I) and epsilon with this dodecamer were estimated to be 9x10(5) and 5x10(4) M(-1), respectively, based on analyses of the CD changes.

引用

页码：1341 / 1349

页数：9

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