CIRCULAR-DICHROISM STUDIES OF CALICHEAMICIN-DNA INTERACTION - EVIDENCE FOR CALICHEAMICIN-INDUCED DNA CONFORMATIONAL CHANGE

被引：30

作者：

KRISHNAMURTHY, G ^{[1
]}

DING, WD ^{[1
]}

OBRIEN, L ^{[1
]}

ELLESTAD, GA ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV MED RES,LEDERLE LABS,PEARL RIVER,NY 10965

来源：

TETRAHEDRON | 1994年 / 50卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)80622-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Evidence from circular dichroism studies suggests that the binding of calicheamicin to DNA induces an optically detectable conformational change of B-form DNA. CD titration of a dodecamer containing a TCCT binding/cleavage site with calicheamicin gamma(1)(I) the aromatized calicheamicin epsilon brings about a decrease primarily in the ellipticity of the positive 270 nm signal. Binding constants for calicheamicin gamma(1)(I) and epsilon with this dodecamer were estimated to be 9x10(5) and 5x10(4) M(-1), respectively, based on analyses of the CD changes.

引用

页码：1341 / 1349

页数：9

共 50 条

[21] CIRCULAR-DICHROISM STUDY OF INTERACTION BETWEEN P-32 AND DNA
GREVE, J
MAESTRE, MF
HOSODA, J
BIOPHYSICAL JOURNAL, 1976, 16 (02) : A15 - A15
[22] STABILIZATION OF A-FORM OF DNA BY MITOMYCIN BINDING - EVIDENCE BY CIRCULAR-DICHROISM
MERCADO, CM
TOMASZ, M
FEDERATION PROCEEDINGS, 1976, 35 (07) : 1494 - 1494
[23] THE LIGHT-INDUCED CONFORMATIONAL CHANGE OF PIGMENT COMPLEXES DETECTED BY CIRCULAR-DICHROISM
LI, CC
PHOTOSYNTHESIS RESEARCH, 1992, 34 (01) : 158 - 158
[24] THERMAL DENATURATION AND CIRCULAR-DICHROISM STUDIES OF PROTAMINE-DNA COMPLEX
YU, S
LI, HJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1973, (AUG26): : 17 - 17
[25] THE ORIGIN OF THE DNA INDUCED CIRCULAR-DICHROISM OF CC-1065 AND ANALOGS
KRUEGER, WC
PRAIRIE, MD
CHEMICO-BIOLOGICAL INTERACTIONS, 1991, 79 (02) : 137 - 149
[26] CONFORMATIONAL TRANSITION OF DNA WITHIN B-FAMILY AS REVEALED BY ANISOTROPY CIRCULAR-DICHROISM
ZAVRIEV, SK
VOLKENSHTEIN, MV
IVANOV, VI
MINCHENKOVA, LE
MOLECULAR BIOLOGY, 1977, 11 (02) : 319 - 322
[27] THE INTERACTION OF RHODIUM(III) WITH DNA BY CIRCULAR-DICHROISM STUDIES - COMPARATIVE BEHAVIOR OF DIMETHYLTIN(IV) AND THALLIUM(I)
KOUTSODIMOU, A
KATSAROS, N
KOVALADEMERTZI, D
TRANSITION METAL CHEMISTRY, 1994, 19 (03) : 260 - 264
[28] CIRCULAR-DICHROISM STUDIES ON DNA CONDENSED IN NACL CETYLTRIMETHYL AMMONIUM BROMIDE SOLUTIONS
MISSELWITZ, R
BECKER, M
BUDER, E
DAMASCHUN, G
ZIRWER, D
ACTA BIOLOGICA ET MEDICA GERMANICA, 1976, 35 (11) : K57 - K61
[29] CIRCULAR-DICHROISM STUDIES OF COMPLEXES OF ANTIBIOTICS DAUNOMYCIN, NOGALAMYCIN, CHROMOMYCIN, AND MITHRAMYCIN WITH DNA
DALGLEISH, DG
FEY, G
KERSTEN, W
BIOPOLYMERS, 1974, 13 (09) : 1757 - 1766
[30] CIRCULAR-DICHROISM STUDIES OF THE BINDING OF ETHIDIUM-BROMIDE TO DNA RESTRICTION FRAGMENTS
SLOBODYANSKY, E
STELLWAGEN, NC
BIOPHYSICAL JOURNAL, 1987, 51 (02) : A509 - A509

← 1 2 3 4 5 →