DELTA-9-TETRAHYDROCANNABINOL REGULATES GENE-EXPRESSION OF THE GROWTH-FACTOR PLEIOTROPHIN IN THE FOREBRAIN

被引：18

作者：

MAILLEUX, P ^{[1
]}

PREUDHOMME, X ^{[1
]}

ALBALA, N ^{[1
]}

VANDERWINDEN, JM ^{[1
]}

VANDERHAEGHEN, JJ ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,FAC MED,UNITE RECH CERVEAU,B-1070 BRUSSELS,BELGIUM

来源：

NEUROSCIENCE LETTERS | 1994年 / 175卷 / 1-2期

关键词：

CANNABIS; THC; CANNABINOID RECEPTOR; CYTOKINE; GROWTH FACTOR; CAUDATE-PUTAMEN; DIAGONAL BAND OF BROCA; CORTEX; (CINGULATE; FRONTOPARIETAL; PIRIFORM); IN SITU HYBRIDIZATION;

D O I：

10.1016/0304-3940(94)91069-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We here studied, by quantitative in situ hybridization at the macroscopic level, the possible modulatory effects of acute THC (5 mg/kg/i.p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain. We found, 30 min after a single injection of THC, a significant increase of PTN mRNA concentrations in the cingulate cortex (38%), fronto-parietal cortex (31%) and caudate-putamen (27%). In conclusion, this is the first report on THC regulation of growth factor gene expression in the brain.

引用

页码：25 / 27

页数：3

共 12 条

[1]

DEWEY WL, 1986, PHARMACOL REV, V38, P151

[2] A RETINOIC ACID RESPONSIVE GENE MK FOUND IN THE TERATOCARCINOMA SYSTEM IS EXPRESSED IN SPATIALLY AND TEMPORALLY CONTROLLED MANNER DURING MOUSE EMBRYOGENESIS [J].

KADOMATSU, K ;

HUANG, RP ;

SUGANUMA, T ;

MURATA, F ;

MURAMATSU, T .

JOURNAL OF CELL BIOLOGY, 1990, 110 (03) :607-616

[3] CLONING AND EXPRESSION OF A DEVELOPMENTALLY REGULATED PROTEIN THAT INDUCES MITOGENIC AND NEURITE OUTGROWTH ACTIVITY [J].

LI, YS ;

MILNER, PG ;

CHAUHAN, AK ;

WATSON, MA ;

HOFFMAN, RM ;

KODNER, CM ;

MILBRANDT, J ;

DEUEL, TF .

SCIENCE, 1990, 250 (4988) :1690-1694

[4] GLUTAMATERGIC REGULATION OF CANNABINOID RECEPTOR GENE-EXPRESSION IN THE CAUDATE-PUTAMEN [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1994, 266 (02) :193-196

[5] DOPAMINERGIC REGULATION OF CANNABINOID RECEPTOR MESSENGER-RNA LEVELS IN THE RAT CAUDATE-PUTAMEN - AN IN-SITU HYBRIDIZATION STUDY [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

JOURNAL OF NEUROCHEMISTRY, 1993, 61 (05) :1705-1712

[6] AGE-RELATED LOSS OF CANNABINOID RECEPTOR-BINDING SITES AND MESSENGER-RNA IN THE RAT STRIATUM [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

NEUROSCIENCE LETTERS, 1992, 147 (02) :179-181

[7] DISTRIBUTION OF NEURONAL CANNABINOID RECEPTOR IN THE ADULT-RAT BRAIN - A COMPARATIVE RECEPTOR-BINDING AUTORADIOGRAPHY AND INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

NEUROSCIENCE, 1992, 48 (03) :655-668

[8] GLUCOCORTICOID REGULATION OF CANNABINOID RECEPTOR MESSENGER-RNA LEVELS IN THE RAT CAUDATE-PUTAMEN - AN IN-SITU HYBRIDIZATION STUDY [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

NEUROSCIENCE LETTERS, 1993, 156 (1-2) :51-53

[9] DELTA-9-TETRAHYDROCANNABINOL REGULATES SUBSTANCE-P AND ENKEPHALIN MESSENGER-RNAS LEVELS IN THE CAUDATE-PUTAMEN [J].

MAILLEUX, P ;

VANDERHAEGHEN, JJ .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1994, 267 (01) :R1-R3

[10] AN 18-KD HEPARIN-BINDING PROTEIN OF DEVELOPING BRAIN THAT IS DISTINCT FROM FIBROBLAST GROWTH-FACTORS [J].

RAUVALA, H .

EMBO JOURNAL, 1989, 8 (10) :2933-2941

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