AN A-DNA TRIPLET CODE - THERMODYNAMIC RULES FOR PREDICTING A-DNA AND B-DNA

被引：59

作者：

BASHAM, B ^{[1
]}

SCHROTH, GP ^{[1
]}

HO, PS ^{[1
]}

机构：

[1] OREGON STATE UNIV, DEPT BIOCHEM & BIOPHYS, CORVALLIS, OR 97331 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 14期

关键词：

DNA STRUCTURE; STRUCTURE PREDICTION; CRYSTALLOGRAPHY; CIRCULAR DICHROISM; SPECTROSCOPY;

D O I：

10.1073/pnas.92.14.6464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ability to predict macromolecular conformations from sequence and thermodynamic principles has long been coveted hut generally has not been achieved. We show that differences in the hydration of DNA surfaces can be used to distinguish between sequences that form A- and B-DNA. From this, a ''triplet code'' of A-DNA propensities was derived as energetic rules for predicting A-DNA formation. This code correctly predicted >90% of A- and B-DNA sequences in crystals and correlates with A-DNA formation in solution. Thus, with our previous studies on Z-DNA, we now have a single method to predict the relative stability of sequences in the three standard DNA duplex conformations.

引用

页码：6464 / 6468

页数：5

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