FUSIDIC ACID ALONE OR IN COMBINATION WITH VANCOMYCIN FOR THERAPY OF EXPERIMENTAL ENDOCARDITIS DUE TO METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

被引:24
作者
FANTIN, B
LECLERCQ, R
DUVAL, J
CARBON, C
机构
[1] UNIV PARIS 07,F-75221 PARIS 05,FRANCE
[2] HOP HENRI MONDOR,SERV BACTERIOL VIROL HYG,F-94010 CRETEIL,FRANCE
[3] UNIV PARIS 12,F-94010 CRETEIL,FRANCE
关键词
D O I
10.1128/AAC.37.11.2466
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The usefulness of fusidic acid, alone or combined with vancomycin, was investigated for the therapy of experimental endocarditis caused in rabbits by a methicillin-resistant strain of Staphylococcus aureus. In vitro killing curves showed an indifferent interaction between the two antibiotics. In vivo, vancomycin alone was as effective as a vancomycin-fusidic acid combination (P < 0.05 versus control animals). No resistance to fusidic acid emerged during combination therapy. Fusidic acid alone was not effective. Resistance emerged in 5 of 12 animals treated with fusidic acid alone and was responsible for antibacterial failure. Fusidic acid alone was effective (P < 0.001) and did not select resistant strains if therapy was started when animals retained a smaller inoculum. We concluded that the vancomycin-fusidic acid combination exhibited no advantage over vancomycin alone in this model.
引用
收藏
页码:2466 / 2469
页数:4
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