CLATHRYNAMIDE-A, CLATHRYNAMIDE-B, AND CLATHRYNAMIDE-C - NOVEL AMIDES FROM A MARINE SPONGE CLATHRIA SP THAT INHIBIT CELL-DIVISION OF FERTILIZED STARFISH EGGS

被引：40

作者：

OHTA, S ^{[1
]}

OKADA, H ^{[1
]}

KOBAYASHI, H ^{[1
]}

OCLARIT, JM ^{[1
]}

IKEGAMI, S ^{[1
]}

机构：

[1] HIROSHIMA UNIV,DEPT APPL BIOCHEM,HIROSHIMA 724,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(00)73818-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel bromine-containing amides, clathrynamides A (1), B (2), and C (3), were isolated from a marine sponge Clathria sp. Their structures were determined on the basis of spectroscopic data. Clathrynamide A (1) significantly inhibited cell division of fertilized starfish eggs and also showed inhibition of the growth of human myeloid K-562 cells in vitro.

引用

页码：5935 / 5938

页数：4

共 4 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].