IMMUNIZATION AND VACCINATION PROTOCOL IN HEMODIALYSIS-PATIENTS WITH NATURALLY ACQUIRED HEPATITIS-B ANTIBODY

被引：1
|
作者：
FARANNA, P [1 ]
COZZI, G [1 ]
BELLONI, M [1 ]
PEDRINI, L [1 ]
机构：
[1] OSPED TRESCORE BALNEARIO,SERV NEFROL & DIALISI,I-24069 TRESCORE BALNEARI,ITALY
来源：
NEPHRON | 1992年 / 61卷 / 03期
关键词：
HEPATITIS-B VACCINATION; ANTI-HBS ANTIBODY; HEMODIALYSIS;
D O I：
10.1159/000186917
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Long-term behavior of naturally acquired anti-HBs antibody was tested every 6 months for 3 years in 22 dialysis patients. Fifteen of them maintained protective levels throughout follow-up (102 and 85.5 m UI/ml at the beginning and the end, respectively). Seven of them became anti-HBs and were submitted to a 40-mu-g booster injection of hepatitis B vaccine. Seroconversion was observed in 6 of 7 patients (85.7%) with a mean anti-HBs titer of 90.4 and 47.3 m UI/ml after 3 and 6 months, respectively. Protective anti-HBs level may be maintained longer in patients with natural immunity than in HBsAg-negative vaccinated subjects. Effectiveness of a reduced vaccination protocol in patients who have lost their natural immunization should be confirmed with further studies.
引用
收藏
页码：311 / 312
页数：2
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