STAGING VITAMIN-B-12 (COBALAMIN) STATUS IN VEGETARIANS

被引:161
|
作者
HERBERT, V
机构
[1] MT SINAI MED CTR, NEW YORK, NY 10029 USA
[2] BRONX VET AFFAIRS MED CTR, NEW YORK, NY USA
来源
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1994年 / 59卷 / 05期
关键词
VITAMIN B-12; SERUM HOLOTRANSCOBALAMIN II; TRANSCOBALAMIN II; COBALAMIN; VEGANS; SERUM TOTAL VITAMIN B-12; SERUM HOLOHAPTOCORRIN; B-12; HAPTOCORRIN;
D O I
10.1093/ajcn/59.5.1213S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
When one stops eating vitamin B-12 (cobalamins), one passes through four stages of negative cobalamin balance: serum depletion [low holotranscobalamin II, ie, low vitamin B-12 on transcobalamin II (TCII)], cell depletion (decreasing holohaptocorrin and low red cell vitamin B-12 concentrations), biochemical deficiency (slowed DNA synthesis, elevated serum homocysteine and methylmalonate concentrations), and, finally, clinical deficiency (anemia). Serum vitamin B-12 is on two proteins: the circulating vitamin B-12 delivery protein, TCII, and the circulating vitamin B-12 storage protein, haptocorrin. Because TCII is depleted of vitamin B-12 within days after absorption stops, the best screening test for early negative vitamin B-12 balance is a measurement of vitamin B-12 on TCII (holoTCII). HoloTCII falls below the bottom of its normal range long before total serum vitamin B-12 (which is mainly vitamin B-12 on haptocorrin) falls below the bottom of its normal range.
引用
收藏
页码:1213S / 1222S
页数:10
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