FLAVONOIDS AS SUPEROXIDE SCAVENGERS AND ANTIOXIDANTS

被引：367

作者：

CHEN, YT ^{[1
]}

ZHENG, RL ^{[1
]}

JIA, ZJ ^{[1
]}

JU, Y ^{[1
]}

机构：

[1] LANZHOU UNIV,DEPT BIOL,LANZHOU 730000,PEOPLES R CHINA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Antioxidation; Flavonoid; Free radicals; Scavenger; Superoxide;

D O I：

10.1016/0891-5849(90)90045-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide anions scavenging activity and antioxidation of seven flavonoids-quercetin, rutin, morin, acacetin, hispidulin, hesperidin, and naringin-were studied. The superoxide anions were generated in a phemazin methosulphate-NADH system and were assayed by reduction of nitroblue tetrazolium. The scavenging activity ranked: rutin was the strongest, and quercetin and naringin the second, while morin and hispidulin were very weak. The concentration values yielding 50% inhibition of lipid peroxidation in mouse liver homogenate were in order of 10-6 M for quercetin, rutin, and morin; and of 10-5 M for acacetin and hispidulin, while naringin and hesperidin had no antioxidative action. In comparison with the antioxidative and scavenging activities of flavonoids, there are no correlations. © 1990.

引用

页码：19 / 21

页数：3

共 50 条

[31] Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells
Lorenz, P
Roychowdhury, S
Engelmann, M
Wolf, G
Horn, TFW
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2003, 9 (02): : 64 - 76
[32] Effect of three flavonoids isolated from Japanese Polygonum species on superoxide generation in human neutrophils
Liu, G
Wang, WF
Masuoka, N
Isobe, T
Yamashita, K
Manabe, M
Kodama, H
PLANTA MEDICA, 2005, 71 (10) : 933 - 937
[33] Superoxide Dismutase-Loaded Porous Polymersomes as Highly Efficient Antioxidants for Treating Neuropathic Pain
Kartha, Sonia
Yan, Lesan
Weisshaar, Christine L.
Ita, Meagan E.
Shuvaev, Vladimir V.
Muzykantov, Vladimir R.
Tsourkas, Andrew
Winkelstein, Beth A.
Cheng, Zhiliang
ADVANCED HEALTHCARE MATERIALS, 2017, 6 (17)
[34] Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro
Jörns, A
Tiedge, M
Lenzen, S
Munday, R
FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (9-10) : 1300 - 1304
[35] Superoxide and nitric oxide in pathological conditions associated with iron overload. The effects of antioxidants and chelators
Afanas'ev, IB
CURRENT MEDICINAL CHEMISTRY, 2005, 12 (23) : 2731 - 2739
[36] The in vitro effects of superoxide, some commercially available antioxidants and red palm oil on sperm motility
Aboua, Yapo Guillaume
du Plessis, Stefan Stephanus
Reichgelt, Patricia
Brooks, Nicole
ASIAN JOURNAL OF ANDROLOGY, 2009, 11 (06) : 695 - 702
[37] Suppression of the formation of megamitochondria by scavengers for free radicals
Wakabayashi, T
Adachi, K
Matsuhashi, T
Wozniak, M
Antosiewicz, J
Karbowsky, M
MOLECULAR ASPECTS OF MEDICINE, 1997, 18 : S51 - S61
[38] Ascorbate abolishes auxotrophy caused by the lack of superoxide dismutase in Saccharomyces cerevisiae yeast can be a biosensor for antioxidants
Zyracka, E
Zadrag, R
Koziol, S
Krzepilko, A
Bartosz, G
Bilinski, T
JOURNAL OF BIOTECHNOLOGY, 2005, 115 (03) : 271 - 278
[39] Flavonoids isolated from the leaves of Melicope triphylla and their extracellular-superoxide dismutase-inducing activity
Oyama, Masayoshi
Nakashima, Ken-ichi
Kamiya, Tetsuro
Haba, Manami
Ito, Tetsuro
Murata, Hiroko
Tanaka, Toshiyuki
Adachi, Tetsuo
Iinuma, Munekazu
Kinoshita, Takeshi
PHYTOCHEMISTRY LETTERS, 2013, 6 (02) : 215 - 218
[40] Antioxidants Improve the Phenotypes of Dilated Cardiomyopathy and Muscle Fatigue in Mitochondrial Superoxide Dismutase-Deficient Mice
Koyama, Hirofumi
Nojiri, Hidetoshi
Kawakami, Satoru
Sunagawa, Tadahiro
Shirasawa, Takuji
Shimizu, Takahiko
MOLECULES, 2013, 18 (02) : 1383 - 1393

← 1 2 3 4 5 →