FLAVONOIDS AS SUPEROXIDE SCAVENGERS AND ANTIOXIDANTS

被引：372

作者：

CHEN, YT ^{[1
]}

ZHENG, RL ^{[1
]}

JIA, ZJ ^{[1
]}

JU, Y ^{[1
]}

机构：

[1] LANZHOU UNIV,DEPT BIOL,LANZHOU 730000,PEOPLES R CHINA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Antioxidation; Flavonoid; Free radicals; Scavenger; Superoxide;

D O I：

10.1016/0891-5849(90)90045-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The superoxide anions scavenging activity and antioxidation of seven flavonoids-quercetin, rutin, morin, acacetin, hispidulin, hesperidin, and naringin-were studied. The superoxide anions were generated in a phemazin methosulphate-NADH system and were assayed by reduction of nitroblue tetrazolium. The scavenging activity ranked: rutin was the strongest, and quercetin and naringin the second, while morin and hispidulin were very weak. The concentration values yielding 50% inhibition of lipid peroxidation in mouse liver homogenate were in order of 10-6 M for quercetin, rutin, and morin; and of 10-5 M for acacetin and hispidulin, while naringin and hesperidin had no antioxidative action. In comparison with the antioxidative and scavenging activities of flavonoids, there are no correlations. © 1990.

引用

页码：19 / 21

页数：3

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