SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL MANNICH BASES OF NORFLOXACIN DERIVATIVES

被引：0
|
作者：
Satyamurthy, K. [1 ]
Sravani, M. [1 ]
Sowjanya, M. [1 ]
SrikanthReddy, M. [1 ]
Jaishankar, M. [1 ]
Kalyani, G. [1 ]
机构：
[1] Teegala Krishna Reddy Coll Pharm, Medbowli,Meerpet,Saroornagar, Hyderabad 500097, Andhra Pradesh, India
来源：
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2015年 / 2卷 / 01期
关键词：
Furoquinolone moiety; IR; H-1; NMR; Cup plate method; Tube dilution method;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Introduction of Furoquinolone moiety, in the synthesis and Biological evaluation of novel mannich bases of Norfloxacin derivatives. The synthesized product was characterized by IR & (HNMR)-N-1 and evaluated for antibacterial activity by cup plate method and tube dilution method. The activity of all synthesized compounds has shown good to mild activity against tested microbes. The compound IId has shown good activity for gram positive bacteria, whereas the compound IIe has shown good activity for gram negative bacteria and compounds IIa, IIb and IIc shows moderate activity.
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页码：502 / 509
页数：8
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