HEM-1, A POTENTIAL MEMBRANE-PROTEIN, WITH EXPRESSION RESTRICTED TO BLOOD-CELLS

被引：19

作者：

HROMAS, R

COLLINS, S

RASKIND, W

DEAVEN, L

KAUSHANSKY, K

机构：

[1] FRED HUTCHINSON CANC RES CTR, DEPT MOLEC MED, SEATTLE, WA 98104 USA

[2] UNIV WASHINGTON, SCH MED, DEPT MED, SEATTLE, WA 98195 USA

[3] UNIV CALIF LOS ALAMOS SCI LAB, DIV LIFE SCI, LOS ALAMOS, NM 87544 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1090卷 / 02期

关键词：

HEMATOPOIESIS; MEMBRANE PROTEIN; PHOSPHORYLATION SITE; CHROMOSOMAL TRANSLOCATION;

D O I：

10.1016/0167-4781(91)90109-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Overlapping cDNAs 3.8 kb in length containing a long open reading frame were obtained that hybridized exclusively to transcripts from hematopoietic cells. Sequence analysis found eight potential membrane domains and two possible cAMP/cGMP phosphorylation sites. This sequence exhibited no homologies with the EMBL/Genbank nucleic acid, SwissProt or GenPept amino acid data bases. The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A.

引用

页码：241 / 244

页数：4

共 19 条

[1]

BLAUSE E, 1983, BIOCHEM J, V209, P331

[2] THE HUMAN HEMATOPOIETIC COLONY-STIMULATING FACTORS [J].