Update on lacrimal gland neoplasms: Molecular pathology of interest

被引：9

作者：

White, Valerie A. ^{[1
,2
,3
]}

机构：

[1] Vancouver Coastal Hlth, Dept Pathol, Vancouver, BC, Canada

[2] Vancouver Coastal Hlth, Lab Med & Ophthalmol & Visual Sci, Vancouver, BC, Canada

[3] Univ British Columbia, Vancouver, BC, Canada

来源：

SAUDI JOURNAL OF OPHTHALMOLOGY | 2012年 / 26卷 / 02期

关键词：

Lacrimal gland neoplasms; Molecular pathogenesis;

D O I：

10.1016/j.sjopt.2012.02.012

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Lacrimal gland neoplasms are rare and much of our knowledge of the behavior and molecular pathogenesis of these tumors comes from study of the similar, but more numerous salivary gland neoplasms. After briefly discussing the classification of lacrimal gland neoplasms, I review three areas of emerging knowledge in the pathogenesis of these neoplasms: (1) the concept of adenoid cystic carcinoma with high-grade transformation and the associated cytogenetic changes; (2) recent analysis of the MYB-NFIB gene fusion in adenoid cystic carcinoma, and; (3) overexpression of HER2 in malignant salivary and lacrimal neoplasms.

引用

收藏

页码：133 / 135

页数：3

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