Impact of contrast-induced acute kidney injury on outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

被引:39
作者
Kume, Kiyoshi [1 ]
Yasuoka, Yoshinori [1 ]
Adachi, Hidenori [1 ]
Noda, Yoshiki [1 ]
Hattori, Susumu [1 ]
Araki, Ryo [1 ]
Kohama, Yasuaki [1 ]
Imanaka, Takahiro [1 ]
Matsutera, Ryo [1 ]
Kosugi, Motohiro [1 ]
Sasaki, Tatsuya [1 ]
机构
[1] Osaka Minami Med Ctr, Div Cardiovasc, Osaka 5868521, Japan
关键词
Renal insufficiency; Contrast-induced acute kidney injury; ST-segment elevation myocardial infarction; Primary percutaneous coronary intervention;
D O I
10.1016/j.carrev.2013.07.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: The purpose of this study was to identify predictors of contrast-induced acute kidney injury (CI-AKI) and the effect of CI-AKI on cardiovascular outcomes after hospital discharge in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Methods and Materials: We retrospectively reviewed 194 STEMI consecutive patients who underwent primary PCI to evaluate the predictors for CI-AKI and 187 survivors to examine all-cause mortality and cardiovascular events. Outcomes were compared between patients with CI-AKI and those without CI-AKI, which was defined as an increase >50% or >0.5 mg/dl in serum creatinine concentration within 48 hours after primary PCI. Results: CI-AKI occurred in 23 patients (11.9%). Multivariate analysis identified pre-procedural renal insufficiency as a predictor of CI-AKI, and this predictor was independent from hemodynamic instability and excessive contrast volume. Receiver-operator characteristics analysis demonstrated that patients with an estimated glomerular filtration rate (eGFR) of = 43.6 ml/min per 1.73 m(2) had the potential for CI-AKI. Patients who developed CI-AKI had higher mortality and cardiovascular events than did those without CI-AKI (27.8% vs. 4.7%; log-rank P =.0003, 27.8% vs. 11.2%; log-rank P = .0181, respectively). Cox proportional hazards model analysis identified CI-AKI as the independent predictor of mortality and cardiovascular events [hazard ratio [HR] = 5.36; P = .0076, HR = 3.10; P = .0250, respectively]. Conclusions: The risk of CI-AKI is increased in patients with pre-procedural renal insufficiency, and eGFR is clinically useful in the emergent setting for CI-AKI risk stratification before primary PCI. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:253 / 257
页数:5
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