Host-guided migration allows targeted introduction of neurons into the embryonic brain

被引:178
作者
Brustle, O
Maskos, U
McKay, RDG
机构
[1] Laboratory of Molecular Biology National Institute of Neurological Disorders, Stroke National Institutes of Health Bethesda
关键词
D O I
10.1016/0896-6273(95)90007-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The stereotyped positions occupied by individual classes of neurons are a fundamental characteristic of CNS cytoarchitecture. To study the regulation of neuronal positioning, we injected genetically labeled neural precursors derived from dorsal and ventral mouse forebrain into the telencephalic vesicles of embryonic rats. Cells from both areas were found to participate in the generation of telencephalic, diencephalic, and mesencephalic brain regions. Donor-derived neurons populated the host brain in distinct patterns and acquired phenotypic features appropriate for their final location. These observations indicate that neuronal migration and differentiation are predominantly regulated by non-cell-autonomous signals. Exploiting this phenomenon, intrauterine transplantation allows generation of controlled chimerism in the mammalian brain.
引用
收藏
页码:1275 / 1285
页数:11
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