PAPILLOMATOUS MELANOCYTIC NEVI - AN ESTROGEN RELATED PHENOMENON

被引：7
作者：
MORGAN, MB
RALEY, BA
VANNARATH, RL
LIGHTFOOT, SL
EVERETT, MA
机构：
[1] UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL,OKLAHOMA CITY,OK 73104
[2] UNIV OKLAHOMA,HLTH SCI CTR,DEPT DERMATOL,OKLAHOMA CITY,OK 73104
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 1995年 / 22卷 / 05期
关键词：
D O I：
10.1111/j.1600-0560.1995.tb00761.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A prospective two-month epidemiologic and histologic study of all melanocytic nevi biopsied (n = 434) at the University of Okla homa Health Center was undertaken. Melanocytic nevi with papillomatous features (PAP) (n=50) were found to occur predominantly in females (females = 44, males = 6; p < 0.01 adjusted for sex distribution of all melanocytic nevi). Immunohistochemical analysis of melanocytic nevi revealed concordance between PAP and intracytoplasmic nevocellular staining for estrogen-inducible pS2 protein. Melanocytic nevi without papillomatous features failed to stain for pS2 protein. These results suggest a hormone responsiveness exclusive of patient sex which may influence the pathogenesis of these distinctive melanocytic nevi.
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页码：446 / 449
页数：4
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