MICROVASCULAR BLOOD VOLUME-TO-FLOW RELATIONSHIPS IN PORCINE HEART WALL - WHOLE-BODY CT EVALUATION IN-VIVO

被引:28
作者
LIU, YH
BAHN, RC
RITMAN, EL
机构
[1] MAYO CLIN & MAYO FDN, DEPT PHYSIOL & BIOPHYS, ROCHESTER, MN 55905 USA
[2] HENRY FORD HOSP, DIV HYPERTENS & VASC RES, DETROIT, MI 48202 USA
[3] MAYO CLIN & MAYO FDN, DEPT MED PATHOL, ROCHESTER, MN 55905 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1995年 / 269卷 / 05期
关键词
ANGIOGRAM; RECRUITMENT; PERFUSION; TRANSIT TIME; MICROSPHERES; EMBOLIZATION;
D O I
10.1152/ajpheart.1995.269.5.H1820
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The goal of this study was to evaluate the functional behavior of recruitable (mostly capillary) and nonrecruitable (mostly arte; rioles and venules) components of the intramyocardial microvasculature in the in situ heart of intact experimental animals. For this purpose fast X-ray computerized tomography (CT) scans were performed in a group of anesthetized pigs. Each scan was performed during an aortic root angiogram and was repeated after sequential injections of a suspension of nonradioactive microspheres into a selected coronary artery. Regional myocardial perfusion (F, ml . g(-1). min(-1)) and intramyocardial blood volume (rho, ml/g) were estimated from the dynamic CT image sequences. For the intramyocardial microcirculation, rho = AF + B root F [where A = 0.016 min and B = 0.076 (ml . min/g)(1/2)] was shown to describe the rho-to-F relationship over the entire range of flows observed. With increasing embolization with 15-mu m diameter microspheres, the coefficients A and B changed in a way consistent with A describing the transit time through the functionally recruitable component and B/root F describing the transit time through the functionally nonrecruitable component of the microcirculation.
引用
收藏
页码:H1820 / H1826
页数:7
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