ENZYMATIC RESOLUTION OF ALPHA-ACETOXYSULFIDES - A NEW APPROACH TO THE SYNTHESIS OF HOMOCHIRAL S,O-ACETALS

被引：23
作者：
MILTON, J
BRAND, S
JONES, MF
RAYNER, CM
机构：
[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] GLAXO RES & DEV LTD,CHEM DEV,STEVENAGE SG1 2NY,HERTS,ENGLAND
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 08期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/0957-4166(95)00248-N
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A novel enzymatic resolution of alpha-acetoxysulfides using Pseudomonas fluorescens lipase is reported. Selectivity is highly dependent on the substrate and solvent, with enantiomeric excesses of >95% in some cases. We believe these are the first examples of enzymatic resolutions of an S,O-acetal.
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页码：1903 / 1906
页数：4
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