A HEAT-STABLE SERUM FACTOR UP-REGULATES 5-LIPOXYGENASE ACTIVITY IN HL-60 CELLS, MODULATION BY TNF-ALPHA OR GM-CSF

被引：8

作者：

STEINHILBER, D ^{[1
]}

RADMARK, O ^{[1
]}

SAMUELSSON, B ^{[1
]}

机构：

[1] UNIV TUBINGEN,DEPT PHARMACEUT CHEM,W-7400 TUBINGEN 1,GERMANY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1736

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Lipoxygenase (5-LO) activity in differentiating HL-60 cells was upregulated by a heat stable protein in human serum. Hematopoietic cytokines were evaluated for this effect on 5-lipoxygenase activity, none of the compounds tested could replace serum. However, TNFα or GM-CSF were able to augment the effect of heat treated serum, giving 5-LO activities that (per cell) were higher than for granulocytes isolated from peripheral blood. The serum factor primarily upregulated 5-LO activity. The amounts of 5-LO protein, or mRNA for 5-LO or 5-lipoxygenase activating protein (FLAP) were less affected. © 1993 Academic Press, Inc.

引用

页码：1083 / 1090

页数：8

共 3 条

[1] GM-CSF UP-REGULATES 5-LIPOXYGENASE AND 5-LIPOXYGENASE ACTIVATING PROTEIN GENE-EXPRESSION IN HUMAN NEUTROPHILS
STANKOVA, J
ROLAPLESZCZYNSKI, M
POIRIER, MJ
DUMOULIN, L
DUBOIS, CM
JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A169 - A169
[2] SERUM FACTORS REGULATE 5-LIPOXYGENASE ACTIVITY IN MATURATING HL-60 CELLS
STEINHILBER, D
HOSHIKO, S
GRUNEWALD, J
RADMARK, O
SAMUELSSON, B
BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1178 (01) : 1 - 8
[3] IL-1, BUT NOT TNF-ALPHA, SYNERGISTICALLY UP-REGULATES GM-CSF-INDUCED B7-1 EXPRESSION OF LANGERHANS CELLS
FURUE, M
CHANG, CH
TAMAKI, K
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (06) : 19 - 19

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