SYNTHESIS OF HIGHLY ENANTIOMERICALLY ENRICHED CYCLIC AMINES BY THE CATALYTIC ASYMMETRIC HYDROGENATION OF CYCLIC IMINES

被引：100

作者：

WILLOUGHBY, CA ^{[1
]}

BUCHWALD, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 27期

关键词：

D O I：

10.1021/jo00079a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric hydrogenation of cyclic ketimines with a chiral titanocene catalyst affords amines with excellent enantioselectivity under a variety of conditions. The reaction is general for cyclic imines of ring size 5-7 and exhibits a high degree of functional group compatibility.

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页码：7627 / 7629

页数：3

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