RATIONAL DESIGN OF POTENT SIALIDASE-BASED INHIBITORS OF INFLUENZA-VIRUS REPLICATION

被引：1522
|
作者：
VONITZSTEIN, M
WU, WY
KOK, GB
PEGG, MS
DYASON, JC
JIN, B
PHAN, TV
SMYTHE, ML
WHITE, HF
OLIVER, SW
COLMAN, PM
VARGHESE, JN
RYAN, DM
WOODS, JM
BETHELL, RC
HOTHAM, VJ
CAMERON, JM
PENN, CR
机构：
[1] CSIRO,DIV BIOMOLEC ENGN,PARKVILLE,VIC 3052,AUSTRALIA
[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
来源：
NATURE | 1993年 / 363卷 / 6428期
关键词：
D O I：
10.1038/363418a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus In cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
引用
收藏
页码：418 / 423
页数：6
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