PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY-REMISSION WITH CYTARABINE

被引：48
作者：
ORIORDAN, T
DALY, PA
HUTCHINSON, M
SHATTOCK, AG
GARDNER, SD
机构：
[1] ST JAMES HOSP,DEPT CLIN HAEMATOL ONCOL,DUBLIN 8,IRELAND
[2] ADELAIDE HOSP,DEPT NEUROL,DUBLIN 8,IRELAND
[3] NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT MED MICROBIOL,REFERENCE LAB,DUBLIN 4,IRELAND
[4] CENT PUBL HLTH LAB,VIRUS REFERENCE LAB,LONDON NW9 5HT,ENGLAND
来源：
JOURNAL OF INFECTION | 1990年 / 20卷 / 01期
关键词：
D O I：
10.1016/S0163-4453(90)92324-E
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A 51-year-old women who was in complete remission from non-Hodgkin's lymphoma, developed a rapidly progressive dementia. Progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of a rising antibody titre to JC polyomavirus in cerebro-spinal fluid and serum and the presence of diffuse white matter changes on magnetic resonance imaging. She was treated initially with intravenous cytarabine and showed minimal improvement. Rapid improvement occurred when intrathecal cytarabine was added and the patient is in complete remission from both lymphoma and PML 20 months later. © 1990 The British Society for the Study of Infection.
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页码：51 / &
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