STEREOSELECTIVE AMINATION OF CHIRAL ENOLATES - SYNTHESIS OF ENANTIOMERICALLY PURE ALPHA,BETA-DIAMINO ACIDS, CHIRAL KEY COMPOUNDS IN THE SYNTHESIS OF CONFORMATIONALLY CONSTRAINED PEPTIDOMIMETRICS AND NON-PEPTIDOMIMETICS

被引：28

作者：

BADORREY, R ^{[1
]}

CATIVIELA, C ^{[1
]}

DIAZDEVILLEGAS, MD ^{[1
]}

GALVEZ, JA ^{[1
]}

机构：

[1] UNIV ZARAGOZA,CSIC,INST CIENCIA MAT ARAGON,DEPT QUIM ORGAN,E-50009 ZARAGOZA,SPAIN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 11期

关键词：

D O I：

10.1016/0957-4166(95)00368-Y

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This work describes an efficient synthesis of enantiomerically pure (R)-2-aminomethylalanine, (R)-2-aminomethylnorvaline, (R)-2-aminomethylvaline, (R)-2-aminomethylleucine and (R)-2-aminomethylphenylalanine by electrophilic amination of chiral 2-cyanoesters with O-(diphenylphosphinyl)hydroxylamine followed by appropiate reduction and hydrolysis.

引用

页码：2787 / 2796

页数：10

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