VERAPAMIL AND FLUNARIZINE INHIBIT PHENCYCLIDINE-INDUCED EFFECTS - AN EEG AND BEHAVIORAL-STUDY IN RATS

被引：14

作者：

POPOLI, P ^{[1
]}

PEZZOLA, A ^{[1
]}

BENEDETTI, M ^{[1
]}

CAROLIS, AS ^{[1
]}

机构：

[1] IST SUPER SANITA,DEPT PHARMACOL,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

NEUROPHARMACOLOGY | 1992年 / 31卷 / 11期

关键词：

VERAPAMIL; FLUNARIZINE; PHENCYCLIDINE; EEG; BEHAVIOR;

D O I：

10.1016/0028-3908(92)90016-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of verapamil and flunarizine on phencyclidine-induced effects has been studied in adult male rats. Both verapamil (25 and 100 mug/10 mul, i.c.v.) and flunarizine (40 and 60 mg/kg, i.p.) significantly reduced behavioural (mean intensity of ataxia, mean duration of head weaving) and the EEG (increase in the mean voltage of background activity of the EEG) effects induced by phencyclidine 5 mg/kg (i.p.). It was reported previously that nimodipine and diltiazem significantly potentiate effects induced by phencyclidine. The contrasting results obtained with verapamil and flunarizine, suggest that these drugs may modulate effects induced by phencyclidine by acting at sites other than NMDA receptor-coupled "L"-type calcium channel.

引用

页码：1185 / 1191

页数：7

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