Localization of advanced glycation endproducts in the kidney of experimental diabetic rats

被引：19
|
作者：
Shikata, K
Makino, H
Sugimoto, H
Kushiro, M
Ota, K
Akiyama, K
Araki, N
Horiuchi, S
Ota, Z
机构：
[1] Third Department of Internal Medicine, Okayama University Medical School, Okayama
[2] Department of Biochemistry, Kumamoto University Medical School, Kumamoto
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 1995年 / 9卷 / 04期
关键词：
D O I：
10.1016/1056-8727(95)80019-B
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization of AGE in the kidney of the streptozotocin-induced diabetic rats immunohistochemically using a monoclonal antibody directed to AGE. In the diabetic rats, glomerular hypertrophy, thickening of the glomerular basement membrane, and expansion of mesangial matrix were observed. AGE was detected in expanded mesangial area and glomerular basement membrane in the kidneys of diabetic rats. The present results suggest that AGE may participate in the development of diabetic nephropathy.
引用
收藏
页码：269 / 271
页数：3
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