ANTIDEPRESSANTS AND BRAIN NEUROCHEMISTRY

被引：53

作者：

RICHELSON, E ^{[1
]}

机构：

[1] MAYO CLIN JACKSONVILLE, DEPT PSYCHIAT, JACKSONVILLE, FL 32224 USA

来源：

MAYO CLINIC PROCEEDINGS | 1990年 / 65卷 / 09期

关键词：

D O I：

10.1016/S0025-6196(12)62747-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Most antidepressant drugs prescribed today have been available for decades. Nonetheless, their mechanism of action in treating depression has remained elusive. On the basis of neurochemical studies in laboratory animals, hypotheses explaining their therapeutic effects have been formulated. The most attractive of these theories involves antidepressant-induced changes in the sensitivity of certain catecholamine and serotonergic receptors in the brain. Support for this hypothesis from clinical studies has been difficult to obtain. Pharmacologic studies of antidepressant drugs, however, indicate the involvement of blockade of neuronal uptake systems for norepinephrine and serotonin and blockade of many receptors for neurotransmitters. These properties of antidepressants can explain some of their adverse effects and certain interactions with other drugs. © 1990, Mayo Foundation for Medical Education and Research. All rights reserved.

引用

页码：1227 / 1236

页数：10

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