THE RSP5-DOMAIN IS SHARED BY PROTEINS OF DIVERSE FUNCTIONS

被引：60
作者：
HOFMANN, K
BUCHER, P
机构：
来源：
FEBS LETTERS | 1995年 / 358卷 / 02期
关键词：
SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; DYSTROPHIN; C2-DOMAIN; YAP65; WW-DOMAIN;
D O I：
10.1016/0014-5793(94)01415-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel, unusually small, and highly conserved domain of modular intracellular proteins is described. The domain was first recognized as three repeats in the yeast rsp5 gene product and named thereafter. The rsp5 protein is thought to interact with nuclear proteins but also contains a C2 domain typical for cytoplasmic proteins. Further analyses revealed several additional occurrences of this domain in diverse protein classes, including cytoplasmic signal transduction proteins, gene products interacting with the transcription machinery, structural proteins like dystrophin, and a putative RNA helicase.
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页码：153 / 157
页数：5
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