SYNTHESIS OF ALPHA,ALPHA-DIALKYLATED AMINO-ACIDS WITH ADENINE OR THYMINE RESIDUES - A NEW MILD AND FACILE HYDROLYSIS OF HYDANTOINS

被引：48

作者：

KUBIK, S ^{[1
]}

MEISSNER, RS ^{[1
]}

REBEK, J ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 36期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)73454-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of alpha,alpha-dialkylated amino acids which contain two adenine or thymine residues in their side chains is presented. In this context, a mild method for the cleavage of hydantoins is introduced.

引用

页码：6635 / 6638

页数：4

共 15 条

[1] REPLICATION AND ASSEMBLY [J].

ANDREU, C ;

BEERLI, R ;

BRANDA, N ;

CONN, M ;

DEMENDOZA, J ;

GALAN, A ;

HUC, I ;

KATO, Y ;

TYMOSCHENKO, M ;

VALDEZ, C ;

WINTNER, E ;

WYLER, R ;

REBEK, J .

PURE AND APPLIED CHEMISTRY, 1993, 65 (11) :2313-2318

[2] LINEAR OLIGOPEPTIDES .223. STRUCTURAL VERSATILITY OF PEPTIDES FROM C-ALPHA,ALPHA-DISUBSTITUTED GLYCINES - PREFERRED CONFORMATION OF THE C-ALPHA,ALPHA-DIPHENYLGLYCINE RESIDUE [J].

CRISMA, M ;

VALLE, G ;

BONORA, GM ;

DEMENEGO, E ;

TONIOLO, C ;

LELJ, F ;

BARONE, V ;

FRATERNALI, F .

BIOPOLYMERS, 1990, 30 (1-2) :1-11

[3] A MILD 2-STEP METHOD FOR THE HYDROLYSIS METHANOLYSIS OF SECONDARY AMIDES AND LACTAMS [J].

FLYNN, DL ;

ZELLE, RE ;

GRIECO, PA .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (14) :2424-2426

[4]

HIROI K, 1968, CHEM PHARM BULL, V16, P444

[5] COMPETITION, COOPERATION, AND MUTATION - IMPROVING A SYNTHETIC REPLICATOR BY LIGHT IRRADIATION [J].

HONG, JI ;

FENG, Q ;

ROTELLO, V ;

REBEK, J .

SCIENCE, 1992, 255 (5046) :848-850

[6]

Kruger G., 1985, HOUBENWEYL METHODEN, VE5, P534

[7] SYNTHESIS OF SOMATOSTATIN ANALOGS INCORPORATING NUCLEO AMINO-ACIDS [J].

LEWIS, I ;

BRUNS, C .

TETRAHEDRON, 1994, 50 (25) :7485-7494

[8] SYNTHESIS OF POTENTIAL ANTICANCER AGENTS .26. ALKYLATION OF 6-CHLOROPURINE [J].

MONTGOMERIE, J ;

TEMPLE, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (03) :630-&

[9] UNCONVENTIONAL NUCLEOTIDE ANALOGUES .2. SYNTHESIS OF ADENYL ANALOGUE OF WILLARDIINE [J].

NOLLET, AJH ;

PANDIT, UK .

TETRAHEDRON, 1969, 25 (24) :5983-&

[10] KINETIC-STUDIES AND MODELING OF A SELF-REPLICATING SYSTEM [J].

NOWICK, JS ;

FENG, Q ;

TJIVIKUA, T ;

BALLESTER, P ;

REBEK, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) :8831-8839

← 1 2 →