POTENTIATION OF GABA-MEDIATED CURRENTS BY CAMP-DEPENDENT PROTEIN-KINASE

被引：63

作者：

KANO, M ^{[1
]}

KONNERTH, A ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,FASSBERG 11,W-3400 GOTTINGEN,GERMANY

来源：

NEUROREPORT | 1992年 / 3卷 / 07期

关键词：

CEREBELLAR PURKINJE CELL; GABA(A) RECEPTOR; CAMP-DEPENDENT PROTEIN KINASE; 8-BROMO-CAMP; PROTEIN KINASE INHIBITOR PEPTIDE; UP-REGULATION;

D O I：

10.1097/00001756-199207000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RECENT reports described a down-regulation of gamma-aminobutyric acid (GABA)-receptor function in several types of central neurones by cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA). Surprisingly, we found that in cerebellar Purkinje cells (PCs) the membrane permeable-compound 8-bromo-cAMP (500-mu-M) induced a long-lasting potentiation of both, whole-cell current responses to bath-applied GABA and amplitudes of miniature inhibitory synaptic currents (mIPSCs). When dialyzing the PCs with the specific protein kinase inhibitor peptide (PKIP, 400-mu-g ml-1), the same manipulation failed to induce a potentiation. These results strongly suggest that, in contrast to its action in other types of neurones, activation of PKA up-regulates the GABA(A) receptor function in cerebellar PCs.

引用

页码：563 / 566

页数：4

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