CRITICAL PERIOD FOR INDUCTION OF CONGENITAL HYDROCEPHALUS AND DYSPLASIA OF SUBCOMMISSURAL ORGAN BY PRENATAL X-IRRADIATION IN RATS

被引：4

作者：

TAKEUCHI, YK ^{[1
]}

TAKEUCHI, IK ^{[1
]}

机构：

[1] AICHI PREFECTURAL COLONY,INST DEV RES,DEPT EMBRYOL,KASUGAI,AICHI 48003,JAPAN

来源：

EXPERIENTIA | 1990年 / 46卷 / 05期

关键词：

Congenital hydrocephalus; critical period; prenatal X-irradiation; rat; subcommissural organ;

D O I：

10.1007/BF01954224

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A single whole-body X-irradiation of pregnant Wistar rats at a dose of 1.05 Gy at 10.30, 12.30 and 14.30 h respectively, of gestational day 10 resulted in significantly high incidences of hydrocephalic offspring. No hydrocephalic offspring resulted from X-irradiation of pregnant rats with 1.05 Gy at 16.30 h whereas a dose of 1.22 Gy at 16.30 h resulted in a low but statistically significant incidence of hydrocephalus. Neither 1.05 Gy nor 1.22 Gy X-irradiation of pregnant rats at 18.30 h resulted in any hydrocephalic offspring. Dysplasia of the subcommissural organ was noticed in all the hydrocephalic brains histologically examined. © 1990 Birkhäuser Verlag.

引用

页码：446 / 449

页数：4

共 9 条

[1]

ADELOYE A, 1976, CHILD BRAIN, V2, P325

[2] HEREDITARY HYDROCEPHALUS IN LABORATORY-ANIMALS AND HUMANS [J].

BRUNI, JE ;

DELBIGIO, MR ;

CARDOSO, ER ;

PERSAUD, TVN .

EXPERIMENTAL PATHOLOGY, 1988, 35 (04) :239-246

[3] GENETIC PRENATAL AQUEDUCTAL STENOSIS WITH HYDROCEPHALUS IN RAT [J].

DAMATO, CJ ;

OSHEA, KS ;

HICKS, SP ;

GLOVER, RA ;

ANNESLEY, TM .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1986, 45 (06) :665-682

[4] INHERITED PRENATAL HYDROCEPHALUS IN THE H-TX RAT - A MORPHOLOGICAL-STUDY [J].

JONES, HC ;

BUCKNALL, RM .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1988, 14 (04) :263-274

[5] SUBCOMMISSURAL ORGAN AND ADJACENT EPENDYMA - AUTORADIOGRAPHIC STUDY OF THEIR ORIGIN IN MOUSE BRAIN [J].

RAKIC, P ;

SIDMAN, RL .

AMERICAN JOURNAL OF ANATOMY, 1968, 122 (02) :317-&

[6]

TAKEUCHI I, 1987, TERATOLOGY, V36, P444

[7]

TAKEUCHI IK, 1986, NEUROTOXICOL TERATOL, V8, P143

[8] ABSENCE OF SUBCOMMISSURAL ORGAN IN THE CEREBRAL AQUEDUCT OF CONGENITAL HYDROCEPHALUS SPONTANEOUSLY OCCURRING IN MT HOKIDR MICE [J].

TAKEUCHI, IK ;

KIMURA, R ;

MATSUDA, M ;

SHOJI, R .

ACTA NEUROPATHOLOGICA, 1987, 73 (04) :320-322

[9] DYSPLASIA OF SUBCOMMISURAL ORGAN IN CONGENITAL HYDROCEPHALUS SPONTANEOUSLY OCCURRING IN CWS/IDR RATS [J].

TAKEUCHI, IK ;

KIMURA, R ;

SHOJI, R .

EXPERIENTIA, 1988, 44 (04) :338-340

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