Preparation and quality control of Lu-177-[tris(1,10-phenanthroline) lutetium(III)] complex for therapy

被引：0

作者：

Yousefnia, Hassan ^{[1
]}

Jalilian, Amir R. ^{[1
]}

Zolghadri, S. ^{[1
]}

Bahrami-Samani, A. ^{[1
]}

Shirvani-Arani, S. ^{[1
]}

Ghannadi-Maragheh, M. ^{[1
]}

机构：

[1] NSTRI, RRDL, Tehran 141551339, Iran

来源：

NUCLEAR MEDICINE REVIEW | 2010年 / 13卷 / 02期

关键词：

lutetium-177; 1,10-phenanthroquinone; biodistribution;

D O I：

暂无

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The Lu-177-[tris(1,10-phenanthroline) lutetium(III)] complex (Lu-177- PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 x 10(13) n. cm(-2). s(-1)) of natural Lu-2(NO3)(3) sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the Lu-177-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild- type male rats and bio- distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.

引用

页码：49 / 54

页数：6

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