SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NOVEL 5-(PYRAZOL-3-YL)THIADIAZOLE AND OXADIAZOLE DERIVATIVES AS POTENTIAL HYPOGLYCEMIC AGENTS

被引：0

作者：

HANNA, MA

GIRGES, MM

RASALA, D

GAWINECKI, R

机构：

[1] MANSOURA UNIV, MANSOURA FAC SCI, MANSOURA 35516, EGYPT

[2] JAN KOCHANOWSKI UNIV HUMANITIES & SCI, INST CHEM, PL-25020 KIELCE, POLAND

来源：

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 1995年 / 45-2卷 / 10期

关键词：

HYPOGLYCEMIC AGENTS; 5-(PYRAZOL-3-YL)THIADIAZOLE AND OXADIAZOLE DERIVATIVES; PHARMACOLOGY; SYNTHESIS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four series of 5-(pyrazol-3-yl) thiadiazole and oxadiazole derivatives (Va-c, VIa-c, VIIIa-c, IXa-c) have been synthesized from 5-arylazo-3-carbethoxy-4-methoxy-1-phenylpyrazole (Ia-c) with a view to investigate their pharmacological activity. The structure of the synthesized products was inferred from elemental and spectral data. The hypoglycemic effect, antimicrobial activity and toxicity of these potential chemotherapeutic agents were evaluated Nineteen of these products were effective, when administered at an oral dose of 100 mg/kg body weight in inducing a marked reduction in blood glucose level.

引用

页码：1074 / 1078

页数：5

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