Silent APC (adenomatous polyposis coli) gene polymorphism in the Portuguese population

被引：0

作者：

Marshall, B ^{[1
]}

Isidro, G ^{[1
]}

Boavida, MG ^{[1
]}

机构：

[1] INST NACL SAUDE DR RICARDO JORGE,DEPT GENET HUMANA,LISBON,PORTUGAL

来源：

GENE GEOGRAPHY | 1995年 / 9卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We describe a new, silent polymorphism in exon 15 of the APC gene on chromosome 5q in the Portuguese population. The polymorphism is located at codon 1442 and results in a CCT-->CCA (Pro) base transversion, with no amino acid change. Population analysis in unrelated healthy controls indicated that the polymorphism was present in 2 out of 50 individuals giving an allele frequency of 0.02 +/- 0.01. The polymorphism is the most common encountered in the Portuguese population in the mutation cluster region of exon 15, and has not been previously described in other populations.

引用

页码：207 / 210

页数：4