Review of EGFR TKls in etastatic NSCLC, including ongoing trials

被引：53

作者：

Melosky, Barbara ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Vancouver Ctr, Med Oncol, 600-10th Ave West, Vancouver, BC V5Z 4E6, Canada

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

EGFRTKI; first-line therapy; erlotinib; gefitinib; afatinib; dacomitinib;

D O I：

10.3389/fonc.2014.00244

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent clinical trials have demonstrated the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in the treatment of patients with advanced metastatic non-small cell lung cancer. Most of these recent trials were conducted in patients with EGFR mutation-positive tumors. As our knowledge of the EGFR mutation and its resistant pathways develops, the complexity of the situation expands. This article briefly reviews the pivotal trials leading to approval of EGFRTKIs in the first-line setting for patients with EGFR mutation-positive non-small cell lung carcinomas. It discusses the historical use of EGFR TKIs after the first-line setting in unselected patients and briefly describes ongoing trials.

引用

页数：4

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