ENANTIOSELECTIVE SYNTHESIS OF BETA-AMINO ACIDS - TMS-SAMP AS A CHIRAL AMMONIA EQUIVALENT FOR THE AZA ANALOGOUS MICHAEL ADDITION TO ALPHA,BETA-UNSATURATED ESTERS

被引：0

作者：

ENDERS, D

WAHL, H

BETTRAY, W

机构：

[1] Institut für Organische Chemie, Technischen Hochschule Aachen, D-52074

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 04期

关键词：

AMINO ACIDS; ASYMMETRIC SYNTHESES; CHIRAL AUXILIARIES; MICHAEL ADDITIONS;

D O I：

10.1002/anie.199504551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The N‐silylated chiral amines TMS‐SAMP and TMS‐RAMP can be employed for stereoselective CN bond formation with enantiomeric excesses of 90‐80%. In these reactions, the corresponding hydrazinoesters are formed initially, which are subsequently cleaved hydrogenolytically to give the desired β‐amino acids 1. R = alkyl, R′ = Me, tBu. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：455 / 457

页数：3

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