THE C-KIT PROTOONCOGENE IN NORMAL AND MALIGNANT HUMAN HEMATOPOIESIS

被引:0
|
作者
RATAJCZAK, MZ [1 ]
LUGER, SM [1 ]
GEWIRTZ, AM [1 ]
机构
[1] UNIV PENN, SCH MED, DEPT INTERNAL MED, PHILADELPHIA, PA 19104 USA
来源
INTERNATIONAL JOURNAL OF CELL CLONING | 1992年 / 10卷 / 04期
关键词
HEMATOPOIESIS; C-KIT; PROTOONCOGENES; LEUKEMIA; ERYTHROPOIESIS; MYELOPROLIFERATIVE DISORDERS;
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The c-kit proto-oncogene encodes a tyrosine kinase receptor (KIT) which is expressed on many types of human cells, including approximately 4% of bone marrow mononuclear cells. Numerous studies attest to the importance of the c-kit receptor and its ligand, known variously as stem cell factor (SCF), mast cell growth factor (MGF), Steel factor (SF), or kit ligand (KL) (the nomenclature we prefer), in the development of human hematopoietic cells. KL, which is produced in membrane-bound and soluble forms by bone marrow stromal cells, acts on pre-colony forming units (pre-CFU) and CFU cells. In synergistic combination with other cytokines, KL enhances the growth of myeloid progenitor cells. However, using an antisense oligodeoxynucleotide strategy to disrupt c-kit function, we have demonstrated that the KL-KIT complex is of greatest importance for generation and/or proliferation of normal human erythropoietic progenitor cells. In malignant hematopoietic cells, the complex also appears to be important for growth of granulocyte/macrophage (GM) CFU as well.
引用
收藏
页码:205 / 214
页数:10
相关论文
共 50 条
  • [21] PROGRESSION OF HUMAN CUTANEOUS MELANOMA IS ASSOCIATED WITH LOSS OF EXPRESSION OF C-KIT PROTOONCOGENE RECEPTOR
    NATALI, PG
    NICOTRA, MR
    WINKLER, AB
    CAVALIERE, R
    BIGOTTI, A
    ULLRICH, A
    INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (02) : 197 - 201
  • [22] IDENTIFICATION OF A POINT MUTATION OF THE PROTOONCOGENE C-KIT IN PATIENTS WITH MASTOCYTOSIS
    NAGATA, H
    WOROBEC, A
    OH, C
    SUZUKI, Y
    METCALFE, DD
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 95 (01) : 176 - 176
  • [23] Intramedullary spinal cord germinoma expresses the protooncogene c-kit
    Watanabe, A
    Horikoshi, T
    Naganuma, H
    Satoh, E
    Nukui, H
    ACTA NEUROCHIRURGICA, 2005, 147 (03) : 303 - 308
  • [24] Immunohistochemical demonstration of c-Kit protooncogene product in gallbladder cancer
    Tanaka, Show
    Tanaka, Hiromu
    Yamamoto, Takatsugu
    Shuto, Taichi
    Takemura, Shigekazu
    Hai, Seikan
    Sakabe, Katsu
    Uenishi, Takahiro
    Hirohashi, Kazuhiro
    Kubo, Shoji
    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 2006, 13 (03): : 228 - 234
  • [25] Intramedullary spinal cord germinoma expresses the protooncogene c-kit
    A. Watanabe
    T. Horikoshi
    H. Naganuma
    E. Satoh
    H. Nukui
    Acta Neurochirurgica, 2005, 147 : 303 - 308
  • [26] DEVELOPMENTAL EXPRESSION OF C-KIT, A PROTOONCOGENE ENCODED BY THE W LOCUS
    ORRURTREGER, A
    AVIVI, A
    ZIMMER, Y
    GIVOL, D
    YARDEN, Y
    LONAI, P
    DEVELOPMENT, 1990, 109 (04): : 911 - 923
  • [27] c-kit is not expressed in malignant mesothelioma
    Horvai, AE
    Li, L
    Xu, ZD
    Kramer, MJ
    Jablons, DM
    Treseler, PA
    MODERN PATHOLOGY, 2003, 16 (08) : 818 - 822
  • [28] EXPRESSION OF THE C-KIT PROTOONCOGENE IN MYELOPROLIFERATIVE DISORDERS AND MYELODYSPLASTIC SYNDROMES
    SIITONEN, T
    SAVOLAINEN, ER
    KOISTINEN, P
    LEUKEMIA, 1994, 8 (04) : 631 - 637
  • [29] EXPRESSION OF C-KIT AND KIT-LIGAND PROTEINS IN NORMAL HUMAN TISSUES
    LAMMIE, A
    DROBNJAK, M
    GERALD, W
    SAAD, A
    COTE, R
    CORDONCARDO, C
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1994, 42 (11) : 1417 - 1425
  • [30] EXPRESSION OF THE YB5.B8 ANTIGEN (C-KIT PROTOONCOGENE PRODUCT) IN NORMAL HUMAN BONE-MARROW
    ASHMAN, LK
    CAMBARERI, AC
    TO, LB
    LEVINSKY, RJ
    JUTTNER, CA
    BLOOD, 1991, 78 (01) : 30 - 37