NEOPLASTIC LESIONS OF QUESTIONABLE SIGNIFICANCE TO HUMANS

被引：83

作者：

ALISON, RH ^{[1
]}

CAPEN, CC ^{[1
]}

PRENTICE, DE ^{[1
]}

机构：

[1] PRECLIN SAFETY CONSULTANTS,HUNTINGDON PE18 8JD,CAMBS,ENGLAND

来源：

TOXICOLOGIC PATHOLOGY | 1994年 / 22卷 / 02期

关键词：

SECONDARY CARCINOGENESIS; SAFETY ASSESSMENT; NEOPLASIA; KIDNEY; STOMACH; MAMMARY GLAND; OVARY; TESTIS;

D O I：

10.1177/019262339402200211

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Many compounds giving a positive result in animal carcinogenicity studies through mechanisms involving secondary carcinogenesis pose little or no risk to humans. This article provides an overview of current understanding, with particular reference to renal tumors in male rats with alpha2mu-globulin nephropathy, urinary bladder neoplasia in rodents, mesovarian leiomyomas induced in rats by beta2-receptor stimulants, carcinoid tumors in the rodent stomach induced by prolonged suppression of acid secretion, thyroid follicular cell tumors in rodents, canine mammary neoplasia due to administration of progestagens, rodent mammary neoplasia induced by estrogens, uterine endometrial carcinomas of rats induced by dopamine agonists, Leydig cell tumors in the testis of rats, and ovarian tubulostromal adenomas in mice. A positive result on a rodent carcinogenicity study should not automatically preclude further development of a compound; future progress in this field should increase the accuracy of the rodent carcinogenicity study as a tool in human safety assessment.

引用

页码：179 / 186

页数：8

共 35 条

[1]

Alden C.L., A review of unique male rat hydrocarbon nephropathy, Toxicol. Pathol, 14, pp. 109-111, (1986)

[2]

Alden C.L., Frith C.H., WM H., CG R., Urinary system., Handbook of Toxicologic Pathology, pp. 315-387, (1991)

[3]

Alison R.H., Morgan K.T., Ovarian neoplasms in F344 rats and B6C3F1 mice, Environ. Health Perspect, 73, pp. 91-106, (1987)

[4]

Alison R.H., Morgan K.T., Haseman J.K., Boorman G.A., Morphology and classification of ovarian neoplasms in F344 rats and (C57BL/6 × C3H)F1 mice, JNCI, 78, pp. 1229-1243, (1987)

[5]

Baetke K.P., Hard G.C., Rodgers I.S., Et al., Alpha2μ-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat, Risk Assessment Forum, (1991)

[6]

Beamer W., Capen C.C., Pathobiology of sterility-associated ovarian tumors in mice, pp. 308-334, (1990)

[7]

Betton G.R., Dormer C., Wells T., Pert P., Price C.A., Buckley P., Gastric ECL cell hyperplasia and carcinoids in rodents following chronic administration of H2 antagonists SK & F 93479 and oxmetidine and omeprazole, Toxicol. Pathol, 16, pp. 288-298, (1988)

[8]

Burek J.D., Patrick D.H., Gerson R.J., HC G., JL C., Weight-of-biological evidence approach for assessing carcinogenicity., Carcinogenicity, pp. 83-95, (1988)

[9]

Capen C.C., DeLellis R.A., Yarrington J.T., WM H., CG R., Endocrine system., Handbook of Toxicologic Pathology, pp. 675-760, (1991)

[10]

Capen C.C., Martin S.L., The effects of xenobiotics on the structure and function of thyroid follicular and C-cells, Toxicol. Pathol, 17, pp. 266-293, (1989)

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