THE PREPARATION OF N-ALKYL-2(1H)-PYRIDONES BY THE REACTION OF AMINES WITH A DERIVATIVE OF 3-(2-PYRIDYL)PROPANE-1,2-DIOL

被引：5

作者：

BLOCK, MH

机构：

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)74744-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of the 2-pyridyl orthoester derivative 7 with DIBAL gives exclusively the secondary alcohol 9 in excellent yield. Mesylation of 9 followed by reaction with amines gives the unusual N-alkyl-2(1H)-pyridones 11 and 12.

引用

页码：8149 / 8150

页数：2

共 5 条

[1] ACID-CATALYZED RACEMIZATION OF 1-(HETEROCYCLYLOXY)-2,3-PROPANEDIOLS [J].

BARLOW, JJ ;

BLOCK, MH ;

HUDSON, JA ;

LEACH, A ;

LONGRIDGE, JL ;

MAIN, BG ;

NICHOLSON, S .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (19) :5158-5162

[2] MILD CLEAVAGE OF METHOXYMETHYL (MOM) ETHERS WITH TRIMETHYLSILYL BROMIDE [J].

HANESSIAN, S ;

DELORME, D ;

DUFRESNE, Y .

TETRAHEDRON LETTERS, 1984, 25 (24) :2515-2518

[3] UNEXPECTED HETEROATOM-ASSISTED C-4 ALKYLATION OF A 1,3-DIOXOLANE [J].

MAROT, C ;

PHILIPP, C ;

ROLLIN, P .

TETRAHEDRON LETTERS, 1992, 33 (32) :4575-4578

[4] A NEW PREPARATION OF N-ALKYL-2(1H)-PYRIDONES FROM 2-GLYCIDOXYPYRIDINES [J].

SCHMIDHAUSER, JC ;

LONGLEY, KL .

TETRAHEDRON LETTERS, 1991, 32 (49) :7155-7158

[5] A CONVENIENT PROCEDURE FOR THE REGIOSELECTIVE MONOPROTECTION OF 1,N-DIOLS [J].

TAKASU, M ;

NARUSE, Y ;

YAMAMOTO, H .

TETRAHEDRON LETTERS, 1988, 29 (16) :1947-1950

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