COLLAGENASE ACTIVITY IN THE CERVIX OF NONPREGNANT AND PREGNANT-WOMEN

被引：26

作者：

OSMERS, R

RATH, W

ADELMANNGRILL, BC

FITTKOW, C

SEVERENYI, M

KUHN, W

机构：

[1] DEBRECEN UNIV MED,DEPT OBSTET & GYNECOL,H-4012 DEBRECEN,HUNGARY

[2] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 1990年 / 248卷 / 02期

关键词：

Cervix uteri; Collagenase; Parturition; Pregnancy;

D O I：

10.1007/BF02389578

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Cervical biopsies were obtained from non pregnant patients and from pregnant at various stages of gestation and during labour. The tissues were extract with a Ca++-containing buffer, and collagenase activity was determined in these extracts using a solid phase assay in which triple helical125I-labelled collagen was cleaved. Collagenase was detected in all samples but significantly elevated activity was only present in labour at 6-8 cm cervical dilatation. This provides direct evidence for the crucial role of specific collagen degradation during cervical ripening and dilatation. © 1990 Springer-Verlag.

引用

页码：75 / 80

页数：6

共 38 条

[1]

ADELMANNGRILL BC, 1982, ARZNEIMITTEL-FORSCH, V32-2, P1357

[2]

DANFORTH DN, 1980, DILATATION UTERINE C, P3

[3] INCREASED POSTPARTUM COLLAGENOLYTIC ACTIVITY IN CERVICAL CONNECTIVE-TISSUE FROM WOMEN TREATED WITH PROSTAGLANDIN-E2 [J].