EPIDERMAL GROWTH-FACTOR IN ACUTE PROMYELOCYTIC LEUKEMIA TREATED WITH RETINOIC ACID

被引:0
作者
WU, XZ
QURESHI, IA
LIU, HN
YIN, JS
QIAN, XP
XU, RJ
机构
关键词
ACUTE PROMYELOCYTIC LEUKEMIA; ALL-TRANS RETINOIC ACID; HUMAN EPIDERMAL GROWTH FACTOR; RELAPSE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We studied 18 patients with acute promyelocytic leukaemia and 13 with relapsed APL. We found a significantly elevated EGF in acute leukaemia, especially in APL, being 418.59 +/- 19.2 mu g in the 24-h urine that was much higher than that of the normal controls. When eight APL patients achieved complete remission by RA treatment, the EGF value decreased to 149.9 +/- 27.3 mu g in the 24-h urine near to normal. In 13 patients with relapsed APL, EGF rose to 446.9 +/- 82.6 mu g in the 24-h urine. Most interestingly, this elevated EGF could be detected before the relapse by 5 +/- 0.84 months in seven out of eight APL with relapse. We suggest that the unaccountably elevated EGF during remission period may be an indicator of the occurrence of relapse.
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页码:83 / 89
页数:7
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