ASYMMETRIC-SYNTHESIS OF 4-PHENYL-1,5-DIAZACYCLOOCTAN-2-ONE USING OPTICALLY-ACTIVE VINYL SULFOXIDES

被引：19

作者：

ITOH, N ^{[1
]}

MATSUYAMA, H ^{[1
]}

YOSHIDA, M ^{[1
]}

KAMIGATA, N ^{[1
]}

IYODA, M ^{[1
]}

机构：

[1] TOKYO METROPOLITAN UNIV, FAC SCI, DEPT CHEM, HACHIOJI, TOKYO 19203, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1995年 / 68卷 / 11期

关键词：

D O I：

10.1246/bcsj.68.3121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Both enantiomers of (S)- and (R)-4-phenyl-1,5-diazacyclooctan-2-ones (7) were synthesized stereo-selectively with good optical purity by the asymmetric conjugate addition of pyrazolidine to optically active vinyl sulfoxides, t-butyl (E)-2-[(R)- and (S)-p-tolylsulfinyl]cinnamates, respectively. Starting from 7, a synthesis of optically active homaline was achieved.

引用

页码：3121 / 3130

页数：10

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