PLATELET-DERIVED GROWTH-FACTOR PROMOTES SMOOTH-MUSCLE MIGRATION AND INTIMAL THICKENING IN A RAT MODEL OF BALLOON ANGIOPLASTY

被引：620

作者：

JAWIEN, A ^{[1
]}

BOWENPOPE, DF ^{[1
]}

LINDNER, V ^{[1
]}

SCHWARTZ, SM ^{[1
]}

CLOWES, AW ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1992年 / 89卷 / 02期

关键词：

PLATELET-DERIVED GROWTH FACTOR; INTIMAL HYPERPLASIA; ARTERIOSCLEROSIS; CHEMOTAXIS; MITOGENESIS;

D O I：

10.1172/JCI115613

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.

引用

页码：507 / 511

页数：5

共 31 条

[1] OBSERVATIONS ON HUMAN SMOOTH-MUSCLE CELL-CULTURES FROM HYPERPLASTIC LESIONS OF PROSTHETIC BYPASS GRAFTS - PRODUCTION OF A PLATELET-DERIVED GROWTH-FACTOR LIKE MITOGEN AND EXPRESSION OF A GENE FOR A PLATELET-DERIVED GROWTH-FACTOR RECEPTOR - A PRELIMINARY-STUDY [J].