IN-VIVO MONOAMINE RELEASE DURING NALOXONE-PRECIPITATED MORPHINE-WITHDRAWAL

被引：18
|
作者：
SILVERSTONE, PH
DONE, C
SHARP, T
机构：
[1] MACKENZIE CTR,DEPT PSYCHIAT,EDMONTON T6G 2B7,AB,CANADA
[2] UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,OXFORD OX2 6HE,ENGLAND
来源：
NEUROREPORT | 1993年 / 4卷 / 08期
关键词：
MORPHINE-WITHDRAWAL; NORADRENALINE; 5-HYDROXYTRYPTAMINE; DOPAMINE; MICRODIALYSIS;
D O I：
10.1097/00001756-199308000-00012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THERE is much evidence from animal work suggesting that the release of noradrenaline (NA) in the brain increases during naloxone-precipitated morphine withdrawal, but the evidence in favour of changes in release of 5-hydroxytryptamine (5-HT) and dopamine (DA) is contradictory. Here we demonstrate, using in vivo microdialysis, that whilst there is a considerable increase (300%) in release of NA in hippocampus precipitated by naloxone in morphine-dependent rats, there is no change in the release of either 5-HT (in hippocampus) or DA (in nucleus accumbens). These results are consistent with suggestions that the symptoms of morphine withdrawal in rats are due primarily to an increase in central NA release.
引用
收藏
页码：1043 / 1045
页数：3
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